Normal Hair Growth and Common Hair Loss



Normal Hair Growth Cycles

Undisturbed, each terminal scalp hair usually grows continuously for about approximately three to five years. The hair transitions into a resting state where the visible portion above the skin is shed. No hair grows from the follicle for 90 days. Once this time has passed, a new hair begins growing through the skin and continues for another three to five years at a rate of approximately 1/2 inch per month.

It is thought that as many as 100 genes are involved in regulating the creation, construction and cycling of scalp hair. To date, very few of these genes have been identified.

Common Pattern Hair Loss

Hamilton-Norwood Hair Loss Scale

For those concerned about hair loss, many myths and half-truths abound, but useful information can be difficult to obtain. An objective overview of pattern hair loss is presented herein.

In healthy well-nourished individuals of both genders, the most common form of hair loss is androgenetic alopecia (AGA), also known as pattern hair loss. The difference between men and women is that a woman suffering hair loss usually retains her feminine hairline and experiences thinning behind this leading edge. In men, a distinct "pattern" of loss manifests where the frontal edge recedes at the same time that a thinning zone expands from the posterior crown.

Three Triggers

Importantly, three things need to occur in order for one to be affected by AGA. One must inherit the genetic predisposition. This means that the problem comes from one or both sides of the family. Second, one needs to attain a certain age. Nine year old children do not experience pattern hair loss. And third, one needs to have the circulating hormones that precipitate onset and progression of the disorder.

Typically, the earliest onset of AGA occurs in late puberty or one's early 20's. As a general rule, the earlier hair loss begins, the more pronounced it is likely to become.

Hormones, Enzymes & Other Factors

Crystallography of DHT molecule
From a susceptibility standpoint, the principle hormonal trigger linked to pattern hair loss is 5-alpha dihydrotestosterone, commonly referred to as DHT. Intriguingly, it has been shown that in persons genetically insensitive to DHT, pattern hair loss does not occur. DHT is synthesized from the androgen hormone testosterone and is useful early in life and during puberty.

In adults, DHT is thought to cause significant harm, but very little good. Disorders as disparate as benign prostatic hyperplasia and pattern hair loss are both triggered by DHT. The synthesis of DHT occurs via two closely related forms of the enzyme 5-alpha reductase. Hair loss treatment options that efficiently interfere with the interaction between 5-alpha reductase and androgen hormones like testosterone have been shown to offer clinical benefit in treating pattern hair loss.

The underlying factors are extremely complex because hair growth is regulated by multiple genes and attendant biochemical pathways. Another challenge to understanding hair loss has been the fact that humans, alone among mammals, suffer from androgenetic alopecia. Thus, no efficient animal model exists that would otherwise tend to shed light upon the key factors at work.

Hair Loss Variations Other Than AGA

In either gender, the differential diagnosis is typically made based on the patient's history and clinical presentation. The common differentials for AGA include alopecia areata (AA), Trichotillomania, and telogen effluvium. Less often, the cause of hair loss may be associated with disorders such as lupus erythematosis, scabies or other skin manifesting disease processes. Scalp biopsy and lab assay may be useful in ascertaining a definitive diagnosis, but, in such cases, should generally only follow an initial clinical evaluation by a qualified treating physician.

Pattern Hair Loss Treatment Options

It has wryly been observed that the choices for dealing with hair loss are "rugs, plugs, or drugs". This quip articulates three treatment options that are more kindly referred to as non-surgical hair systems, surgical hair restoration, and pharmacotherapy.

Non-surgical Restoration

Typical Hair Piece

Hair replacement systems have been in regular use at least since the time of ancient Egypt. These products also go by the term hair integration systems, wigs, weaves, hair pieces, toupees and many other names.

The first is the hair itself which may be synthetic, natural, or a combination thereof. Typically, the hair is woven in to a fabric-like base which is then attached in some fashion to the scalp. Methods include sewing the base to the fringe hair, gluing the base to the fringe hair, or gluing the base to the bald scalp.

Potential advantages to hair systems include the immediacy of achieving a full hair "look" that can appear, to the casual observer, to approximate a full head of hair. The potential disadvantages of hair systems are many and varied.

In persons who are actively losing hair, vs. those who are essentially bald, the hair system itself may rapidly accelerate the process of going bald. Another disadvantage is the hard leading edge that can give away the fact that a person is wearing a hair system. In the past, this problem has been addressed by using delicate lace front artificial hairlines that look quite natural but tend to be extremely fragile.

Because they are nonliving, hair systems must be serviced and eventually replaced themselves. The costs of servicing and maintaining a hair replacement system are not insubstantial-- and such costs can dramatically exceed the initial price of acquisition.

Surgical Hair Restoration

Surgical hair restoration, commonly known as hair transplantation, exploits a phenomenon first described in the 1950's. This phenomenon, donor dependence refers to the observation that hair bearing tissue, when relocated to a previously balding area of the same person's scalp, continues to produce viable, vigorously hair that persists in its new location as it otherwise would, had it not been "relocated". In appropriately selected patients, surgical hair restoration can constitute a positive solution to pattern hair loss

There are important caveats to hair transplantation. Thus, both operator and patient are relegated to whatever permanent hair bearing tissue is in place.

A hair line that is too abrupt or spotty may look worse than it did before it was restored. By the same token, hair behind the leading edge that is not restored in a fashion that yields meaningful density (e.g. 1 hair per mm/sq) often fails to approximate a full head of hair.

The third caveat to hair transplantation refers to a problem known as chasing a receding hair line. Because hair loss is progressive and relentless, it is possible that donor hair restored integrated into an apparently intact area of scalp hair may end up as an island of hair because the hair behind it continues to erode.

Ideally, for persons undergoing transplant surgery, it would be helpful to incorporate a treatment option that safely and effectively arrested the progression of hair loss, allowing the treating surgeon to fill in the thin areas without the concern of chasing a receding hair line.

Drug-based Hair Loss Treatment Options

From a treatment perspective, the two most widely used therapeutic interventions against pattern hair loss have been topical minoxidil and oral finasteride.

Minoxidil

Minoxidil, first sold under the trade-name Rogaine( TM) was initially developed as the oral antihypertensive drug, Loniten( TM). In some patients who used minoxidil to treat blood pressure problems, it was observed that unusual hair growth occurred on the face and scalp. Rogaine( TM) (2% minoxidil) was the first hair loss treatment drug approved by the FDA for use in men.

The advantages of Rogaine( TM) include the ability to arrest, and possibly reverse, pattern hair loss. Based on Pfizer's own marketing materials, Rogaine( TM) has primarily been shown to be effective in treating hair loss in the vertex and posterior scalp, but not the anterior hairline. Minoxidil is a potent drug with potential side effects that include hypotension and skin irritation.

Finasteride

Finasteride, a selective type II 5-alpha reductase inhibitor was originally developed, in 5 mg oral dosage, under the trade name Proscar( TM) to treat benign prostatic hyperplasia (BPH). Because BPH is linked biochemically to the same metabolic pathways that trigger pattern hair loss, it was hypothesized that finasteride could be clinically useful in both pathologies. In placebo-controlled studies on men with mild to moderate hair loss, Propecia( TM) was shown to produce clinically relevant benefit in arresting, and in some cases, reversing the progression of the disorder.

Dutasteride

Like finasteride, dutasteride was originally developed to treat BPH. Unlike finasteride however, dutasteride inhibits both isoforms of 5-alpha reductase, while finasteride inhibits only type II more info 5-alpha reductase. Interestingly, a clinical study undertaken by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH.

At the present time, dutasteride is approved to treat BPH. Clinical trials for dutasteride as a hair loss drug were undertaken, but halted in late 2002. Potential side effects noted with the use of dutasteride include gynecomastia, changes to PSA levels, teratogenic effects and others that closely parallel the negative side effect profile described by the makers of finasteride.

In December 2006, GlaxoSmithKline embarked on a new Phase III, six month study in Korea to test the safety, tolerability and effectiveness of a once-daily dose of dutasteride (0.5 mg) for the treatment of AGA in the vertex region of the scalp (types IIIv, IV and V on the Hamilton-Norwood scale). The future impact that this study will have on the FDA's approval or disapproval of Avodart for the treatment of male pattern baldness in the United States is yet to be determined.

Other Drugs

On occasion, but specifically in female patients drugs including spironalactone & flutamide have, on occasion been used off-label to treat various forms of hair loss. Each drug comes with a host of potential side effects, and none has been approved by the FDA for the treatment of pattern hair loss.

Non-drug based Hair Loss Treatment Options

Recently, botanically derived substances have come under serious investigation as potentially useful tools against AGA. This effort has been largely pioneered by the makers of HairGenesis(TM). After the creation of HairGenesis(TM) a number of other products came on the market. Some incorporated drugs like minoxidil. Others, used variations on the theme of non-drug based formulations. Aside from HairGenesis(TM), none has been supported with a third party, IRB monitored, placebo-controlled, double blind study-- published in the peer-reviewed medical literature. This makes HairGenesis(TM) unique in the category. For those wishing to see how HairGenesis(TM) is thought to compare to other hair loss treatment options, a review of the HairGenesis(TM) Comparison Page is encouraged.

Inasmuch as the bulk of this website focuses on the benefits associated with HairGenesis(TM), the numerous points in favor of HairGenesis(TM) treatment will not be reiterated herein. Two points are relevant to the present discussion, however, and will be concisely articulated.

The complex of naturally derived active substances used in HairGenesis(TM) have been shown to operate through pathways and mechanisms that are unique from one another, as well as separate and apart from those within which drug-based treatments work. Suffice to say that this observation has presented a unique opportunity to develop HairGenesis into a "cocktail" treatment wherein formulation synergy would most likely occur.

In plain English, this means that HairGenesis(TM) has been designed to be greater than the sum of its parts.


In healthy well-nourished individuals of both genders, the most common form of hair loss is androgenetic alopecia (AGA), also known as pattern hair loss. These products also go by the term hair integration systems, wigs, weaves, hair pieces, toupees and many other names. Surgical hair restoration, commonly known as hair transplantation, exploits a phenomenon first described in the 1950's. By the same token, hair behind the leading edge that is not restored in a fashion that yields meaningful density (e.g. 1 hair per mm/sq) often fails to approximate a full head of hair. Because hair loss is progressive and relentless, it is possible that donor hair restored integrated into an apparently intact area of scalp hair may end up as an island of hair because the hair behind it continues to erode.

Outdoor Fun With Inflatable Bounce Houses



With summer around the corner it's time for parents to start thinking about ways to get their kids away from the TV and computer and outside for fresh air, exercise and fun. Unless your kids have a reason to venture outside they probably won't, preferring to idle the hours away with television re-runs, video games and social networking. If there is a giant, colorful bounce house in the front or back yard you may want to stay clear of the door as they rush to the carnival like amusement toy.

Bounce houses, also known as jumpers or combo jumpers are safe inflatable structures that provide hours of fun for kids of all ages. Available in a wide variety of themes and with options for obstacle courses, race courses and even water slides inflatable jumpers are one of the best outdoor toys you can find for occupying a young child's imagination.

Bounce houses and jumper combos are designed to withstand heavy use and the materials used are commercial grade and puncture proof so even big kids and adults can get in on the fun. Most bounce houses inflate in just a few minutes with a strong UL blower that can be placed at a safe distance from the structure with a long fill tube so it doesn't interfere with the action.

Large pillars are conveniently placed in strategic areas of the inflatable house structure to provide a sturdy and durable frame that won't collapse under pressure or weight. Many inflatable jumpers and combo jumpers come with instructions for assembly and even repair kits to do minor patch repairs on your own.

Inflatable jumpers are great for large families and any kid party celebration. Unlike swing sets, trampolines and other outdoor activity sets that need constant adult supervision to prevent injury bounce houses are much safer and when you keep the number of kids in the structure to a safe maximum there is very little you have to worry about in terms of injuries and accidents. Many bounce house sets inflatables Cincinnati feature high quality safety netting in open areas to prevent falls and the amount of air blown into to the structure is sufficient to prevent anyone from hitting the ground.

Bounce houses can be rented for day parties or purchased so you have a full-time indoor and outdoor play set for your kids. No matter what your kids are in to you'll have no trouble finding an inflatable jumper theme to match their interests including pirate ships, castles, jungle safaris, monster trucks, sports arenas and much more.

For great deals on bounce houses, inflatable jumpers and other fun kid party games go to Inflatable 2000 and get ready to let the good times roll.


If there is a giant, colorful bounce house in the front or back yard you may want to stay clear of the door as they rush to the carnival like amusement toy.

Unlike swing sets, trampolines and other outdoor activity sets that need constant adult supervision to prevent injury bounce houses are much safer and when you keep the number of kids in the structure to a safe maximum there is very little you have to worry about in terms of accidents and injuries. Many bounce house sets feature high quality safety netting in open areas to prevent falls and the amount of air blown into to the structure is sufficient to prevent anyone from hitting the ground.

Involved In A Car Accident? Why You Should See A Chiropractor



Car accidents can leave you confused and excited at the same time that you survived the accident. This is a situation that often leaves those involved in the accident ignoring symptoms of injuries that could have been sustained during the collisions. Failure to pay attention to your body after an accident can lead to chronic conditions that only show you later and can cost you time and money to heal and treat.

Whereas it is common for most people to go for medications and surgery when they are victims of the accidents, it is very important that you consider seeing a chiropractor no matter how minor the accident impact might seem to you. Here are some reasons why you should see a chiropractor after you have been involved in a car accident.

Some injuries are not obvious. Bruises, cuts and broken bones may be very easy to identify but others, such as whiplash may not be that obvious after an accident. A chiropractor uses the necessary techniques to identify, control damage, reduce swelling and minimize pain.

2. Chiropractic treatments are not invasive. Instead of waiting for days and weeks and sometimes even months before you can start treatment for injuries and symptoms that show up later, thus leading to costly procedures, your chiropractor will help ease the burden using non-invasive treatments. Massage, ice and heat exercises, stretches and packs are some of the commonly used techniques in chiropractic treatments. They offer quick pain relief and tackle underlying symptoms before they become major issues, costly to treat through invasive surgeries.

Minor injuries if left untreated, can either heal without needing any medical treatment or they can develop into more serious medical conditions. Immediate chiropractic care helps you take the guess work off your injuries and boost chances to speed full recovery after the accident.

When you see a car accident chiropractor, you will have an easier time linking the injuries to the accident so you can get the compensation that you deserve. Waiting too long to get treatment and diagnosis makes it harder to prove that you got the injuries from the accident.

5. You will avoid pain medications and needles. Because chiropractic care approaches the pain and injuries with natural pain management techniques before resolving to anything else, this is. Apart from reducing pain, the techniques increase blood flow and strengthen muscles getting you benefits you would not have enjoyed when using medication.

Auto accident injury should never be ignored no matter how minor it looks. Choose a good auto injury chiropractor for diagnosis and treatment in the most effective natural way.


Car accidents can leave you confused and excited at the same time that you survived the accident. Whereas it is common for most people to go for medications and surgery when they are victims of the accidents, it is very important that you consider seeing a chiropractor no matter how minor the accident impact might seem to you. Immediate chiropractic care helps you take car accident Charlotte NC the guess work off your injuries and boost chances to speed full recovery after the accident.

When you see a car accident chiropractor, you will have an easier time linking the injuries to the accident so you can get the compensation that you deserve. Waiting too long to get treatment and diagnosis makes it harder to prove that you got the injuries from the accident.

Lose Weight Fast and Safe - 2 Things You Need to Have In Order to Make Fat Melt Fast



Are you looking for ways to lose weight fast and safe, but growing tired of never being able to find a solution? With so many diet options to choose from, it can be tough to find the right diet that not only helps you shed weight fast, but does it safely, too. Thankfully, there are ways to drop pounds quickly and safely, and you're about to find out how!

You see, many people make weight loss something far more difficult than it really ought to be. It's quite simple to lose fat if you don't let yourself get in the way! Plus, you can do it safely without putting your health at risk.

With that said, here are 2 things you need to have if you want to lose weight fast and safe:

# 1 - You MUST Have the Desire

Dropping weight is incredibly simple when you not only want to lose the weight, but you have a burning passion or a DESIRE to get the body of your dreams. That's one of the most crucial elements to determining your success. If you lack the desire, how can you expect to lose weight fast?

Try to imagine yourself with a sexy and sleek body. Imagine how much better it would make you feel. What could you do that you can't do right now? Think about it and get that imagine into your head, as it will help instill that burning desire inside of you.

# 2 - You NEED to Map Out a Plan

It's true - there is now way you can lose weight fast without having a detailed plan completely mapped out. Without a clear idea of where you are and where you want to go, you're basically stuck somewhere in the middle, and you'll always be stuck there unless you sit down and create a clear and concise plan to where you feel you NEED to be.

Having a clear diet and fitness plan is absolutely crucial if you want to lose weight safe and fast.

Now with all of that said, do you want to know the truth about losing weight and how you can drop pounds quickly and safely?

Take it from me - I dropped 25 pounds in less than 30 days! Click here now to see how I did it and discover the best way to burn fat faster than you ever thought possible!


Are you looking for ways to lose weight fast and safe, but growing tired of never being able to find a solution? With so many diet options to choose from, it can be tough to find the right diet that not only helps you shed weight fast, but does Deutschland Schnell Abnehmen it safely, too. Dropping weight is incredibly simple when you not only want to lose the weight, but you have a burning passion or a DESIRE to get the body of your dreams. If you lack the desire, how can you expect to lose weight fast?

How to Choose Metal Lockers

Very often I hear people say that a locker is a locker, and that there is no big distinctions between different products.

I think this is really far from true. In fact there are some details that make difference between metal lockers and, more broadly, metal furnishing.

In this article I try to list some details you should pay attention to.

1) Kind of metal. Of course there is big differences between ordinary steel (varnished) and stainless steel. Obviously stainless steel lockers are better because they guarrantee more cleanliness and offer a longer life (Stainless steel does not stain, corrode or rust as easily as ordinary steel), but they are more expensive. If you have to put lockers in a humid place, stainless steel is a good choice.

This is really an important detail because the life of Umkleidespinde mit Sitzbank your lockers could be very shorter due to a bad paint work. It's important that lockers are painted with epoxy powder, and so pay attention to this particular.

3) Ventilation holes. It's important that lockers have a good inner ventilation since they have to contain clothes. Inner ventilation, of course, depends on holes and so pay attention to this detail.

Ususally you need to close your lockers and so ensure that a closing system is gived. Very often if you choose cylindrical lock you can also have a pass-key.


Obviously stainless steel lockers are better because they guarrantee more cleanliness and offer a longer life (Stainless steel does not stain, corrode or rust as easily as ordinary steel), but they are more expensive. Stainless steel is a good choice if you have to put lockers in a humid place.

It's important that lockers are painted with epoxy powder, and so pay attention to this particular. It's important that lockers have a good inner ventilation since they have to contain clothes.

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